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OpenTrials
Completed

NCT Number: NCT02033005

Newborn Feeding and Infant Phenotype

Breast feeding is believed to be beneficial to long-term health but how these effects are mediated is unknown. I suggest that this may be through effects on body composition and metabolism.

I will compare adipose tissue and liver fat deposition in healthy, full term breast and formula fed infants babies shortly after birth and around 12 weeks.

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Key information

Conditions

Breast Feeding Behavior Feeding Behavior

Age range

Up to 4 week

Sex eligibility

All sexes

Study type

Observational

Primary location

Chelsea and Westminster Hospital NHS Foundation Trust

London, SW10 9NH, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy baby
  • Term baby
  • Appropriate weight for gestational age (UK - WHO 2009 growth charts)

Exclusion criteria

  • Infants of diabetic mothers
  • Infants of smokers
  • Infants fed non-commercial or non-cows milk based infant formulae

Treatment and study plan

Primary outcomes

  1. Change in Total Adipose Tissue Volume

    Time frame: Between birth and 6-12 weeks age

    Difference in total adipose tissue volume, measured using whole body magnetic resonance imaging.

Secondary outcomes

  1. Change in Regional Adipose Tissue Distribution Compared to Breastfed Infants.

    Time frame: Between birth and 6-12 weeks age

    Change in regional adipose tissue distribution (ratio of internal abdominal to total subcutaneous abdominal adipose tissue) measured using whole body magnetic resonance imaging

  2. Change in Intrahepatocellular Lipid Compared to Breastfed Infants.

    Time frame: Between birth and 6-12 weeks age

    Change in intrahepatocellular lipid (IHCL) compared to breastfed infants, measured using in-vivo hepatic magnetic resonance spectroscopy

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Collaborators

  • Chelsea and Westminster NHS Foundation Trust

Registry information

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Jan 10, 2014
Registry last updated
Nov 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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