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Completed

NCT Number: NCT01919957

Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.

Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

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Key information

Conditions

Epilepsy, Unspecified, Pharmacologically Resistant Brain Diseases Central Nervous System Diseases Epilepsy Memory Disorders Memory Impairment Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital

Paris, 75651 Cedex 13, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with drug-resistant epilepsy
  • Age of 18 years or more
  • Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
  • Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
  • Covered by a social security system
  • Signing of consent form

Exclusion criteria

  • Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
  • Refusal to consent form
  • Contraindications to MRI
  • Pregnancy
  • Refusal to be informed in the case of detection of an abnormality during the experiment

Treatment and study plan

Primary outcomes

  1. Measure of successfull encoding

    Time frame: 8 years

    Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI

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Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques

Acronym: MemO-Epi

Important dates

Study start
2013
Primary completion
2021
Study completion
2022
First posted
Aug 9, 2013
Registry last updated
Sep 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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