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Completed

NCT Number: NCT01792011

Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation

The aim of this study is to compare the accuracy of PVI (pleth variability index)

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Key information

Conditions

Hemodynamic Instability

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation

Malatya, 44315, Turkey (Türkiye)

About this study

The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective living donor liver transplantation,
  • >18 years patients

Exclusion criteria

Patients with:

  • Arrhythmia
  • Reduced left ventricular function (EF<40%)
  • Hepatocellular carcinoma
  • Pulmonary hypertension
  • Fulminant liver failure
  • valvular heart disease

Treatment and study plan

PVI-guided fluid management

Device

In this study of 25 adult patients undergoing OLT, we prospectively record PVIwithin 5 minutes during dissection and anhepatic phase of OLT by Masimo pulse oximeter.In this study of 25 adult patients undergoing OLT, we prospectively record study data within 5 minutes during dissection and anhepatic phase of OLT. Study data included measurements of PVI,thermodilution cardiac output, Stroke volume variation (SVV) and Pulse pressure variation (PPV).

Primary outcomes

  1. To test the ability of PVI to detect changes in preload during orthotopic liver transplantation

    Time frame: During dissection and anhepatic phase (3 months)

    PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle

Interested in participating?

Completed

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Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

Accuracy and Utility of the Pleth Variability Index as a Predictor of Fluid Responsiveness During the Dissection and Anhepatic Phase of Liver Transplantation

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 15, 2013
Registry last updated
Feb 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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