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NCT Number: NCT01736384

Can Genetic Markers Predict Weight Loss After Gastric By-pass Surgery

There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Karolinska Institutet, Danderyds Hospital, Stockholm, Sweden

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • laparoscopic gastric by-pass with BMI greater than 35

Exclusion criteria

  • unable to understand swedish

Treatment and study plan

Gastric bypass or cholecystectomy

Procedure

Primary outcomes

  1. Genetic markers

    Time frame: day of surgery and 1 and 2 years after surgery

    Blood samples and tissue biopsies taken at the time of surgery and at follow-up.

Secondary outcomes

  1. Lipid and protein patterns in plasma and tissues

    Time frame: day of surgery and at 1 and 2 years postoperatively

    Blood samples taken and tissue biopsies taken at the time of surgery and at follow-up

  2. Previous viral infection

    Time frame: At time of surgery

    Blood samples taken before surgery

  3. Genexpression and comorbid disease

    Time frame: At time of bariatric surgery and 1-2 years postoperatively

    Gene expression studies in tissue biopsies and whole blood at time of surgery and follow-up

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Danderyd Hospital
  • Ersta Hospital, Sweden
  • Karolinska University Hospital

Registry information

Official study title

Can Genetic Changes Predict Weight Loss and Outcome After Bariatric Surgery and Can it Related to Virus Infection and Function of Liver and Adipose Tissue as Well as Lipid and Protein Profiles.

Important dates

Study start
2009
Primary completion
2020
Study completion
2020
First posted
Nov 29, 2012
Registry last updated
Feb 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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