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OpenTrials
Completed

NCT Number: NCT01501578

Pulmonary Fibrosis and Telomerase Mutation Study

This study is an observational and retrospective study of patients with pulmonary fibrosis associated or not with telomerase mutation.

The purpose of this study is to describe in detail the cases with telomerase mutation in terms of features on CT scan, respiratory function and evolution, in comparison to control subjects with idiopathic pulmonary fibrosis and no telomerase mutation identified or family history.

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Key information

Conditions

Pulmonary Fibrosis Fibrosis Lung Diseases Lung Diseases, Interstitial Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Louis Pradel Hospital (Bâtiment A4)

Lyon, 69677, France

About this study

Two "control" subjects will be enrolled for one subject with telomerase mutation.

The data are all the results of investigations conducted for the diagnosis of idiopathic pulmonary fibrosis and during routine follow up of patients.

The CT scans will reviewed centrally to homogenize the description.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diffuse interstitial lung disease on CT scan
  • Telomerase mutation analysis

Exclusion criteria

  • Presence of connective tissue disease, or pneumoconiosis or drug induced lung disease

Treatment and study plan

Primary outcomes

  1. Description of imaging pattern

    Time frame: at baseline only

    Description of imaging pattern on representative CT scan at diagnosis.

Secondary outcomes

  1. Pathology of the lung

    Time frame: at baseline only

    description of pathological pattern

  2. Pulmonary function tests

    Time frame: from diagnosis to last follow-up, for an average of one year

    analyze the respiratory function

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires

Other

Collaborators

  • Bichat Hospital

Registry information

Official study title

Phenotype of Pulmonary Fibrosis Associated With a Mutation of Telomerase

Important dates

Study start
2011
Primary completion
2012
Study completion
2015
First posted
Dec 29, 2011
Registry last updated
Feb 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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