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OpenTrials
Completed

NCT Number: NCT01437462

Sevoflurane, Propofol, Postoperative Pain

The impact of anaesthetic method (intravenous vs. inhalational) has been proposed, but not proven in a large-scale study. The researchers aim to provide an investigation that has sufficient power to clarify the potential effect of anaesthetic method on postoperative need of opioids. Sevoflurane and propofol will be compared.

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Key information

Conditions

Healthy Adults Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gynecological Disease Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Signs and Symptoms Urogenital Diseases

Age range

18 year–69 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Tampere University Hospital

Tampere, 33521, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-69 years
  • Gender: female
  • ASA status 1-3
  • Laparoscopic hysterectomy

Exclusion criteria

  • Body Mass Index over 35
  • Diabetes mellitus
  • Liver disease
  • Allergies to pharmaceuticals used in the Study
  • Present use of opioids

Treatment and study plan

Sevoflurane

Drug

Sevoflurane inhalation anesthesia, sufficient amount to maintain adequate general anesthesia for surgery

Other names: Baxter Sevofluran

Propofol

Drug

Propofol intravenous anesthesia, sufficient amount to maintain adequate anesthesia during surgery

Other names: Propofol Lipuro

Primary outcomes

  1. Postoperative consumption of an opioid (oxycodone)

    Time frame: 20 hours

    The consumption of oxycodone will be monitored by recording the amount of the drug received via a commercially available patient controlled analgesia (PCA) pump.

Secondary outcomes

  1. NRS (numeral rating scale) of pain

    Time frame: 20 hours

    NRS is evaluated frequently during the study period.

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Sponsors and collaborators

Lead sponsor

Tampere University Hospital

Other

Registry information

Official study title

Postoperative Pain After Propofol Sevoflurane Anaesthesia: a Prospective, Randomized, Single-blinded Trial

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Sep 21, 2011
Registry last updated
Apr 10, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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