Pharmacodynamics of Lorelin Depot (Leuprorelin Acetate - Bergamo) Compared to Lupron Depot ® (Leuprorelin Acetate - Abbot)

Inclusion criteria

• Accept the Informed Consent.
• Subjects of research males aged 40 to 45 years;
• Subject of research with body mass index greater than or equal to 19 and less than or equal to 30;
• Be considered healthy, from the analysis of the clinical history and medical examination;
• Laboratory tests with results outside the values considered normal, but not considered clinically relevant.

Exclusion criteria

• Have donated or lost 450 mL or more of blood in the three months preceding the study;
• Have participated in any experimental study or have taken any experimental drug in the last three months prior to the start of the study;
• Have made regular use of medication in the last 4 weeks prior to the start of the study or have made use of any medication a week before the study began;
• Have been hospitalized for any reason, up to 8 weeks before the study;
• Provide history of alcohol abuse, drugs or medications, or have ingested alcohol within 48 hours prior to the period of hospitalization;
• Have a history of liver disease, renal, pulmonary, gastrointestinal, hematological or psychiatric;
• Amendments pressure of any etiology requiring pharmacological treatment;
• Present history of myocardial infarction, angina and / or heart failure.