Viral Triggers in Pediatric Lung Transplantation

The purpose of this study is to determine whether respiratory viral infections increase the risk of bronchiolitis obliterans syndrome (BOS), obliterative bronchiolitis (OB), death, or retransplantation in children who have received lung transplants.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Lung Transplant Bronchial Diseases Bronchiolitis Bronchiolitis Obliterans Bronchitis Lung Diseases Lung Diseases, Obstructive Obliterative Bronchiolitis Respiratory Tract Diseases

Age range

Up to 21 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University, Palo Alto, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Parent or legal guardian willing and able to provide informed consent
Participant of first single or bilateral heart-lung transplant

Exclusion criteria

Recipient of multi-organ transplant (aside from heart-lung)
Condition or characteristic which in the opinion of the investigator makes the participant unlikely to complete the study

Treatment and study plan

Primary outcomes

The earliest time to BOS or OB, retransplantation or death

Time frame: Within 24 months of transplant

Secondary outcomes

Time to each of the following events: BOS or OB, retransplantation or death

Time frame: Within 24 months of transplant

Interested in participating?

Completed

Looking for future studies?

Notify Me

Sponsors and collaborators

Lead sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Nih

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation (CTOTC-03)

Important dates

Study start: 2009
Primary completion: 2015
Study completion: 2015
First posted: May 1, 2009
Registry last updated: Jul 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed