Evaluation of AN777 in Elderly Subjects

Inclusion criteria

• Subject (male or female) is at least 65 years of age
• Subject has a Geriatric Nutritional Risk Index (GNRI)of 92 or over
• Subject has Body Mass Index (BMI) > 20.0 but <30.0
• Subject is ambulatory
• Subject agrees to maintain current activity level

Exclusion criteria

• Subject has undergone major surgery, less than 4 weeks prior to enrollment in the study
• Subject has current active malignant disease, except basal or squamous cell skin carcinoma or carcinoma in situ of the uterine cervix
• Subject has stated immunodeficiency disorder
• Subject has stated history of diabetes
• Subject has stated presence of partial or full artificial limb
• Subject has stated kidney disease
• Subject has stated history of uncontrollable hypertension
• Subject had myocardial infarction within the last 3 months
• Subject had recent antibiotic use (within 1 week prior to screening).
• Subject has a history of allergy to any of the ingredients in the study products
• Subject has an obstruction of the gastrointestinal tract precluding ingestion of the study product, inflammatory bowel disease, short bowel syndrome or other major gastrointestinal disease
• Subject has stated uncontrolled severe diarrhea, nausea or vomiting
• Subject has untreated clinically significant ascites, pleural effusion or edema
• Subject has known dementia, brain metastases, eating disorders, history of significant neurological or psychiatric disorder or any other psychological condition that may interfere with study product consumption
• Subject is actively pursuing weight loss
• Subject is currently taking medications/dietary supplements/substances that could profoundly modulate metabolism or weight Exceptions for multi-vitamin/mineral supplement, inhaled steroids for asthma or chronic obstructive pulmonary disease, topical or optical steroids and short-term use (less than two weeks) of dexamethasone