Identification of Novel Targets for Regulation of Adipose Tissue Mass

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Heidelberg

Heidelberg, 69115, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants of the OPTIFAST52 program
BMI > 30 kg/m2

Exclusion criteria

Rejection of informed consent by the participant

Treatment and study plan

Optifast

Dietary Supplement

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Primary outcomes

number of adipocytes and preadipocytes under weight loss

Time frame: three years

Secondary outcomes

metabolic function of adipocytes and preadipocytes under weight loss

Time frame: three years

Sponsors and collaborators

Lead sponsor

Gottfried Rudofsky

Other

Collaborators

Swiss Federal Institute of Technology

Registry information

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Oct 16, 2008
Registry last updated: Aug 23, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed