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Recruiting

NCT Number: NCT00722527

Molecular Biology of Polycythemia and Thrombocytosis

Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that causes these disorders. When this is accomplished, new therapies to control and eventually cure the disorder can be designed.

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Key information

Conditions

Polycythemia Blood Platelet Disorders Bone Marrow Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hypoxia Myeloproliferative Disorders Pathological Conditions, Signs and Symptoms Polycythemia, primary familial and congenital Signs and Symptoms Signs and Symptoms, Respiratory Thrombocytosis

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Utah

Salt Lake City, Utah, 84132, United States

Location status: Recruiting

About this study

Our hypothesis is that genes and their mutation are causative of certain types of polycythemia and thrombocytosis. These will be sought for by genetic and cell biology means. The purpose of the study is to identify the molecular defect of these disorders.

5-7 teaspoons of peripheral blood will be drawn on all study subjects. After DNA is obtained, linkage analysis and/or mutation analysis will be performed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with an elevated hemoglobin concentration (>18 in males and >16 in females)
  • Subjects with an elevated platelet count (>450,000)

Exclusion criteria

  • Subjects who have a known acquired cause of polycythemia and thrombocytosis
  • Subjects with heart disease, left to right heart shunt or severe pulmonary disease

Treatment and study plan

Primary outcomes

  1. Identify the molecular defect of Polycythemic and Thrombocythemic disorders

    Time frame: Weekly

Interested in participating?

Recruiting

Interested in participating?

Request Info

Sponsors and collaborators

Lead sponsor

University of Utah

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Important dates

Study start
2006
Primary completion
2028
Study completion
2028
First posted
Jul 25, 2008
Registry last updated
Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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