Effect of Dietary Polyphenols on Insulin Sensitivity

A large and growing segment of the population is prediabetic. Dietary interventions that improve insulin sensitivity may be important in preventing the progression to full-blown diabetes in these individuals. Foods and dietary compounds that increase insulin sensitivity are likely to help maintain a healthier body composition. This pilot study will provide data to evaluate the role of dietary plant polyphenols in improving insulin sensitivity.

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Key information

Conditions

Insulin Resistance Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nutritional and Metabolic Diseases

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

About this study

How does the amount consumed of cocoa and tea polyphenols (flavon-3-ol monomers and oligomers) affect insulin sensitivity in insulin resistant individuals?

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Individuals who are insulin resistant based on routine clinical measurements (Stern et al., 2005).

Exclusion criteria

BMI < 27 kg/m²
Age < 25 and > 65 years
Pregnant women or women who plan on becoming pregnant during the study
Postpartum women
Lactating women
Diabetes mellitus
Kidney disease
Liver disease
Certain cancers
Smokers

Treatment and study plan

Polyphenols (flavon-3-ol monomers and oligomers)

Other

Flavanols

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Sponsors and collaborators

Lead sponsor

United States Department of Agriculture (USDA)

Fed

Registry information

Important dates

Study start: 2006
Primary completion: 2007
Study completion: 2007
First posted: Apr 29, 2008
Registry last updated: Apr 29, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed