Multicenter Myocardial Viability Trial

The purpose of this study is to test the hypothesis of whether contrast enhanced Magnetic Resonance Imaging can be used to predict improvement of the wall motion in regions of the heart with abnormal movement following bypass surgery or percutaneous angioplasty in various institutions across three continents.

Completed

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

21 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cliniques Universitaires St. Luc, Brussels, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: > 21 years and < 85 years
Sinus rhythm
Weight < 120 kg
LVEF > 30%
Wall motion abnormality on Echo. or LV-gram
Scheduled for revascularization - Angioplasty/Stent or CABG - within 30 days

Exclusion criteria

Resting heart rate > 100 bpm
Frequent atrial or ventricular ectopy
Severe aortic stenosis or HOCM
Unstable angina
Myocardial infarction within 14 days
Active congestive heart failure
Pregnancy
Known allergy to gadolinium
Contraindication to MRI

Treatment and study plan

Primary outcomes

To examine whether the extent of irreversible myocardial injury as assessed by Delayed Enhancement Magnetic Resonance Imaging can predict the extent of functional recovery after revascularization in patients with chronic coronary artery disease (CAD).

Time frame: 36 months

Sponsors and collaborators

Lead sponsor

CHI St. Luke's Health, Texas

Other

Collaborators

Medtronic - MITG

Registry information

Official study title

An International, Multicenter Trial Assessing Myocardial Viability With Contrast - Enhanced Magnetic Resonance Imaging

Important dates

Study start: 2003
Primary completion: 2011
Study completion: 2011
First posted: Apr 18, 2008
Registry last updated: Dec 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed