Postpartum Thyroid Measures and Mood

Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.

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Key information

Conditions

Postpartum Depression Depression, Postpartum Depressive Disorder Female Urogenital Diseases and Pregnancy Complications Mental Disorders Mood Disorders Pregnancy Complications Puerperal Disorders Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Oklahoma State University Center for Health Sciences Houston Park Obstetrics Clinic

Tulsa, Oklahoma, 74107, United States

About this study

This small pilot study was an attempt to corroborate a relationship between quantified mood and thyroid measures, using the numerical scores obtained from a common depression screen, the Edinburgh Postnatal Depression Scale (EPDS), as a continuum. Mood scores were compared with presence of thyroid autoantibodies and plasma concentrations of free T4 and TSH.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Over 18 years of age
In third trimester of pregnancy when recruited
Negative for the following drugs detected by a urine drug screen:

Amphetamines
Barbiturates
Benzodiazepines
Cocaine
Opiates
Phencyclidine metabolites (PCP), and tricyclic antidepressants
Vaginal delivery
Screened negative for major depressive disorder on the Edinburgh Postnatal Depression Scale (EPDS) at her prenatal enrollment in the study
Receiving a score of 12 or lower out of a possible 30

Exclusion criteria

Under age 18
Positive for any of the following drugs:

Amphetamines
Barbiturates
Benzodiazepines
Cocaine
Opiates
Phencyclidine metabolites (PCP), and tricyclic antidepressants
Cesarean delivery
EPDS score over 12 at prenatal screening test

Treatment and study plan

Primary outcomes

Numerical score on the Edinburgh Postnatal Depression Scale

Time frame: seven weeks

Interested in participating?

Completed

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Sponsors and collaborators

Lead sponsor

Oklahoma State University Center for Health Sciences

Other

Registry information

Important dates

Study start: 2000
Study completion: 2001
First posted: Nov 29, 2007
Registry last updated: Jan 28, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed