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OpenTrials
Completed

NCT Number: NCT00559806

The Effect of Aging and Immobilisation on Muscle

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

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Key information

Conditions

Healthy Atrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

20 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Sports Medicine, Bispebjerg Hospital

Copenhagen, 2400-NV, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion criteria

  • Musculoskeletal disorder
  • Diabetes
  • Cardiovascular disease
  • Neurological diseases; or
  • Cognitive disorders

Treatment and study plan

2 weeks of unilateral immobilisation and 4 weeks of resistance training

Other

2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

Primary outcomes

  1. muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation

    Time frame: 2 weeks of immobilisation and 4 weeks of resistance training

Secondary outcomes

  1. single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number

    Time frame: 2 weeks of imm and 4 weeks of resistance training

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Registry information

Important dates

Study start
2007
Study completion
2007
First posted
Nov 16, 2007
Registry last updated
Nov 16, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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