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OpenTrials
Completed

NCT Number: NCT00550121

Does Ascorbic Acid Reduce Sympathoexcitation in CHF?

In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF

Completed

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Radboud University Nijmegen Medical Centre

Nijmegen, 6500 HB, Netherlands

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Heart failure of at least New York Heart Association (NYHA) class II
  • Left ventricular ejection fraction (LVEF) <= 40%
  • Age 20-80 years

Exclusion criteria

  • Necessity of short-term PCI, CABG or heart transplantation,
  • Chronic disease of the autonomic nervous system,
  • diabetes mellitus,
  • use of tricyclic antidepressant drugs and/or a-adrenergic receptor antagonists.

Treatment and study plan

Vitamin C

Drug

Placebo

Drug

Primary outcomes

  1. change in central sympathetic output after vitamin C vs. placebo

Interested in participating?

Completed

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Sponsors and collaborators

Lead sponsor

Radboud University Medical Center

Other

Collaborators

  • ZonMw: The Netherlands Organisation for Health Research and Development

Registry information

Important dates

Study start
2007
Study completion
2008
First posted
Oct 26, 2007
Registry last updated
Oct 15, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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