GPIAG and Leicester Asthma and Dysfunctional Breathing (GLAD) Study: a Randomised Controlled Study

Breathing retraining supervised by a physiotherapist will result in improvements in the quality of life and asthma control of patients treated for asthma in the community with symptoms suggestive of dysfunctional breathing.

To investigate the effects of breathing retraining on clinical and physiological parameters of asthma control, to identify the characteristics of patients who benefit, to perform a health economic evaluation.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

17 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

About this study

Objectives:

To assess the effect of breathing retraining on asthma-related health status, asthma control and objective indices of asthma severity (bronchial hyper-reactivity (BHR), sputum eosinophilia and nitric oxide production) in patients with symptomatic asthma.
To compare the relationship between symptoms of dysfunctional breathing (Nijmegen Questionnaire screening score), changes in asthma-related health status and other parameters resulting from breathing retraining
To explore the relationship between dysfunctional breathing, baseline asthma symptoms, treatment and asthma-related quality of life.
To estimate the cost effectiveness of the breathing retraining intervention

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Asthma diagnosis in medical records
Age 17-70 yrs.
One or more prescription for asthma medication in previous 12 months
Impaired asthma related quality of life (AQLQ score <5.5)

Exclusion criteria

COPD
Unstable or under-treated asthma at enrollment.

Treatment and study plan

physiotherapist

Other

Physiotherapist administered breathing retraining programme

Primary outcomes

Change in AQLQ scores between intervention and control groups in subjects with positive NQ screening scores 1 month post intervention Change in AQLQ scores between intervention groups of subjects with positive and negative NQ screening scores

Time frame: Dec 2006

Secondary outcomes

Changes in bronchial hyperresponsiveness(PC 20), sputum eosinophil counts and exhaled NO between intervention and control groups in subjects with positive and negative NQ screening scores Change in ACQ Score between the intervention and the control gr

Time frame: Dec 2007

Sponsors and collaborators

Lead sponsor

P Burns

Other

Collaborators

University Hospitals, Leicester

Registry information

Acronym: GLAD

Important dates

Study start: 2003
Primary completion: 2007
Study completion: 2007
First posted: Aug 14, 2007
Registry last updated: Nov 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed