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OpenTrials
Completed

NCT Number: NCT00497016

Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Radboud University Medical Center Nijmegen

Nijmegen, 6500 HB, Netherlands

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • (Known) hypertension
  • stable drug therapy for at least 2 months
  • age 18-70 jaar
  • BMI 18-35 kg/m2
  • Sinusrhythm

Exclusion criteria

  • Recent cardiovascular event <6 mnd
  • Plasma Creatinin:
  • female: >120 mmol/L
  • male: >133 mmol/L
  • use of:
  • tricyclic antidepressants
  • alpha-1 -and/or alpha-2 blockers
  • disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
  • Albuminuria >300 mg/dag

Treatment and study plan

Atorvastatin 80 mg

Drug

Primary outcomes

  1. change in central sympathetic activity

Secondary outcomes

  1. change in cholesterol levels, renin and aldosteron

Interested in participating?

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Sponsors and collaborators

Lead sponsor

Radboud University Medical Center

Other

Collaborators

  • ZonMw: The Netherlands Organisation for Health Research and Development

Registry information

Important dates

Study start
2007
Study completion
2008
First posted
Jul 6, 2007
Registry last updated
Sep 30, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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