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NCT Number: NCT00431548

Retinal Oxygen Reactivity in Patients Infected With Human Immunodeficiency Virus (HIV)

Ocular lesions, including cotton wool spots and retinal hemorrhage, are a common feature of HIV infection and acquired immunodeficiency syndrome (AIDS). The aetiology of these apparently vasoocclusive phenomena in HIV related retinopathy is not well understood. Several hypotheses including infectious damage of the retinal vasculature and altered retinal hemodynamics have been postulated. The latter would be compatible with the theory that the retina of HIV patients is hypoxic. However, direct measurement of oxygen tension in the retina is not possible and indirect methods have to be employed. The study objective was to investigate the reactivity in retinal blood flow to 100% oxygen breathing in patients with HIV.

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Key information

Conditions

HIV Infections Blood-Borne Infections Communicable Diseases Genital Diseases Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Ocular Physiology RNA Virus Infections Retina Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Urogenital Diseases Virus Diseases

Age range

19 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Clinical Pharmacology, Medical University of Vienna

Vienna, 1090, Austria

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group 1 (Patients with HIV)

  • Aged between 19 and 70 years, male and female
  • HIV positive patients without HIV-related retinopathy with a CD4+ cell count  500 cells/mm3 stage A2, A3, B2, B3, C2 and C3.
  • Best corrected visual acuity >= 0.8
  • Ametropy < 6 dpt

Group 2 (Healthy control subjects)

  • Aged between 19 and 70 years
  • Age and sex matched to the subjects in the HIV group (group matched)
  • Matched with regard to the smoking habits in the HIV group
  • Best corrected visual acuity >= 0.8
  • Ametropy < 6 dpt

Exclusion criteria

  • Evidence of any other eye disease
  • Diabetes mellitus
  • Systemic hypertension (defined as SBP > 150 mmHg or DBP > 90 mmHg)
  • Abuse of illegal drugs

Treatment and study plan

100% O2

Drug

Primary outcomes

  1. Reactivity in retinal blood flow during 100% O2 breathing expressed as percent change

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Official study title

Retinal Oxygen Reactivity in Patients Infected With Human Immunodeficiency Virus (HIV).

Important dates

First posted
Feb 6, 2007
Registry last updated
Feb 6, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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