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OpenTrials
Completed

NCT Number: NCT00319943

Computer-Based Therapy for Mild Cognitive Impairment

The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).

Completed

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of California, San Francisco

San Francisco, California, 94143, United States

About this study

The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1)65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function.

3)Fluency in English 4)Willing to meet the time commitment of the study

-

Exclusion criteria

  • Clinically significant cerebrovascular disease
  • Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -

Treatment and study plan

Computer-based training for Mild Cognitive Impairment (MCI)

Procedure

Primary outcomes

  1. The study investigates changes in a neuropsychological assessment battery pre-randomization

  2. and upon the completion of training.

Secondary outcomes

  1. Early evaluations will be conducted from brain imaging; specifically, date

  2. obtained via positron emission tomography (PET), magnetoencephalography (MEG),

  3. electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)

  4. studies.

Sponsors and collaborators

Lead sponsor

Posit Science Corporation

Industry

Collaborators

  • Stanford University
  • University of California, Davis
  • University of California, San Francisco

Registry information

Important dates

Study start
2004
Study completion
2006
First posted
Apr 27, 2006
Registry last updated
Apr 27, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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