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Completed

NCT Number: NCT00203346

Research Study Examining Nerve Block for Migraine

Migraine and the skin sensitivity that accompanies it can go away in minutes after a nerve block, which is a procedure involving an injection of a small amount of a local anesthetic next to a nerve to the skin, causing an area of skin to become numb. We have also noticed that light sensitivity goes away quickly after a nerve block. We would like to see how quickly this happens and how long the benefit of nerve block lasts. We are interested to see if these effects are due to the injection itself or due to the lidocaine.

A subject may be asked to participate in this study if a subjects physician has planned for a subject to receive an injection of BOTOX® in the area of the Greater Occipital Nerve (a spinal nerve located at the back of the head) as part of a subjects routine preventive treatment for migraine today.

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Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jefferson Headache Center

Philadelphia, Pennsylvania, 19107, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with episodic or transformed migraine age 18to 80 years old.
  • Subjects must have unilateral migraine headache and trigeminal distribution brush allodynia at the time of injection.
  • Subjects must be able to consent or assent to the study.

Exclusion criteria

  • Subjects who in their own or in the investigator's opinion are unable to report the severity of four symptoms (pin sharpness to determine efficacy of nerve block, headache severity, photophobia severity and allodynia severity), every 30 seconds for 5 minutes post injection;
  • Subjects with skull defect, or history of injury to the area of the GON.
  • Subjects with prior adverse reaction to GON block, lidocaine or marcaine.
  • Subjects who are pregnant or lactating

Treatment and study plan

Greater occipital nerve block

Procedure

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Sponsors and collaborators

Lead sponsor

Thomas Jefferson University

Other

Registry information

Official study title

Greater Occipital Nerve (GON) Block for Migraine

Important dates

Study start
2005
First posted
Sep 20, 2005
Registry last updated
Jan 23, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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