Effect of Glutathione on Blood Alcohol and Hangover Symptoms

Type of Study: Double-blinded control

Population: 100 males

Inclusion criteria

• Males 20-40 years
• Healthy, without chronic diseases, especially must have normal hepatic function, measured by serum SGPT
• No history of alcoholic allergy
• Drink alcohol regularly, at least once a week
• Agree to be a subject by standard consent form

Exclusion criteria

• Subject wants to end the study
• Some impending danger to subjects

Number of subjects : 100

Methodology

• Subjects are recruited;
• History taking, physical examination and SGPT are done by M.D.;
• 100 subjects are distributed randomly to numbers 1-100;
• Factory provides 2 groups of capsules in randomized packets numbered 1 -100; each package contains 3 sub-packages; each sub-package contains 2 capsules of either placebo or 370 mg glutathione capsules. All the three sub-packages will be all placebo or all glutathione. 50 packages are placebo and 50 packages are glutathione;
• Subjects are examined as follows:

• Hour 0: 3 ml of blood taken for blood alcohol and blood acetaldehyde;
• Hour 0- 1: consume Thai Whisky (40% alcohol) 60 ml with snacks;
• Hour 1: ml of blood taken for blood alcohol and blood acetaldehyde;
• Hour 1.30: ml of blood taken for blood alcohol and blood acetaldehyde;
• Hour 2.30: ml of blood taken for blood alcohol and blood acetaldehyde;
• Hour 3.30: ml of blood taken for blood alcohol and blood acetaldehyde;
• Hour 12: ml of blood taken for blood alcohol and blood acetaldehyde, and Alcohol Hangover Symptom evaluation of each subject is done individually.

Using Wendy S. Slutske et al Scale 0-4:

0= no symptom

• minimal
• some
• much
• most

Symptoms are

• extreme thirst or dehydration
• more tired than usual
• headache
• nausea
• vomiting
• very weak
• difficulty concentrating
• more sensitive to light and sound than usual
• more sweating than usual
• have a lot of trouble sleeping
• anxious
• depressed
• trembling or shaking

Blood alcohol, blood acetaldehyde and hangover symptoms are statistically evaluated for significance.

Inclusion criteria

• Healthy
• Males 20-40 years old
• No allergies to alcohol

Exclusion criteria

• Chronic disease
• Increase in hepatic enzyme SGPT
• Impending danger