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NCT Number: NCT06923254

7.0T Magnetic Resonance Imaging Study for Hepatic Encephalopathy

This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).

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Key information

Conditions

Hepatic Encephalopathy (HE) Brain Diseases Brain Diseases, Metabolic Central Nervous System Diseases Digestive System Diseases Hepatic Encephalopathy Hepatic Insufficiency Liver Diseases Liver Failure MRI Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases fMRI Research

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

In this study, we analyzed the imaging characteristics of HE. First, with the advantages of 7TMRI, we analyzed the differences in imaging characteristics between HE patients and the healthy, including brain functional imaging and structural imaging. Second, we analyzed the differences in imaging characteristics between different subgroups of HE patients. Finally, we analyzed the correlation between the prognostic results of HE patients after follow-up and the imaging characteristics.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with clinical suspected or diagnosed hepatic encephalopathy according to relevant guidelines.The patient's education level is above primary school level.
  • Regular follow-up.

Exclusion criteria

  • Contraindications to MRI.
  • Patients with cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease.

Treatment and study plan

7.0T MRI-Scan

Other

7.0T MRI-Scan

Primary outcomes

  1. Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects.

    Time frame: 5 years

    Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）.

Secondary outcomes

  1. Correlation between spectral features of clinical variables and spectral features of imaging.

    Time frame: 5 years

    The clinical variable spectrum characteristics were constructed using the patients' medical records and test data. The distribution characteristics of clinical psychological characteristics and imaging spectrum characteristics were compared using a multidimensional matrix, and gene-imaging association analysis was used to evaluate imaging changes.

Study contacts

Contact information is provided by the study sponsor or research team.

Jing Tang

CONTACT

[email protected]

+8618001184224

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2029
Study completion
2030
First posted
Apr 11, 2025
Registry last updated
Apr 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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