5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression

• Ontario Registrar General Death database. Use the COD_primary variable (used from 2003 onwards) to define suicide, based on an ICD10 code of X60-X84.
• NACRS: X60-84 (dx10code1-dx10code10) AND dead on arrival or death after arrival (visdisp2002 = 10 or 11). Consider admission date the date of the event.
• OMHRS: Discharge reason (dischreason (X90) = 2). Died from suicide. Consider admission date the date of the event.
• CIHI-DAD (Consider admission date the date of the event):

i. suicide=1, or ii. dx10code1-25= ICD10 X60-84 AND dischdisp="07".

• NACRS: presentation to the emergency room: ICD 10 codes X60-X84 (intentional self harm).
• OMHRS: admission with suicide ideation.

i. Self injury attempts: D1A or selfinjury_attempt=3, 4, 5, or 6 ii. Self injury intent: D1B or selfinjury_intent=1 iii. Self injury considered: D1C or selfinjury_cons=3, 4, 5 or 6 iv. Self injury plan: D1DB or suicide_plan=1

• Any CIHI-DAD/SDS ICD 10 code, OR
• Any OMRHS code Axis1_dsm4code1-19 or Axis2_dsm4code 1-7 OR
• Look for any OHIP record billed by Mainspecialty = "PSYCHIATRY" with a diagnosis of depression OHIP dxcode 311, OR
• ≥2 GP visits within 2 years AND both with OHIP dxcode 311

i. OHIP dxcode: 311 ii. ICD 10: F32.0, F32.1, F32.2, F32.3, F32.8, F32.9, F33.0, F33.1, F33.2, F33.3, F33.4, F33.8, F34.1 iii. Psychiatry visits defined as any of these OHIP fee codes: A195, A895, A190, A795, A695, A395, A196, A193, A194, A191, A192 iv. OMHRS: 29620-29626, 29630-29636, 31100 (major depressive disorder)