3D Printed Customized Bone Graft for Alveolar Regeneration: Longitudinal Cohort Evaluation

This study will evaluate the behavior of the implant-supported restorations (prosthesis) placed into the areas grafted with the 3D printed customized bone (personalized graft produced to fit a specific bone defect), as well as the volume contraction of the printed bone.

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Key information

Conditions

Periodontal Diseases Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Bone Loss Stomatognathic Diseases

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systemically healthy individuals
over 18 years of age
Subjects that received regenerative surgical treatment by customized 3D printed blocks.
Subjects must agree to participate in the study and agree to sign the Informed Consent.

Exclusion criteria

Subjects with ilness that avoid their presence to the clinical evaluation
ISubjects who have lost the customized blocks
Subjects who do not agree to participate in the study will be excluded.

Treatment and study plan

Clinical evaluation

Other

Clinical parmeters and radiographical analysis

Primary outcomes

Periodontal Clinical Parameter of the implants Placed in the Grafted area

Time frame: 5 years

Marginal Bone Loss < 2mm

Secondary outcomes

Bone Graft Volume Alteration

Time frame: 6 years

Tomographic Volumetric Measurement (mm3) of the 3D printed graft after a period ranged between 1 to 6 years

Study contacts

Contact information is provided by the study sponsor or research team.

Jamil A Shibli, DDS, PhD

CONTACT

[email protected]

+55 11 982593439

Sponsors and collaborators

Lead sponsor

University of Guarulhos

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Feb 12, 2026
Registry last updated: Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed