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NCT Number: NCT07297615

3D Liver Volumetry

The study aims to improve preoperative evaluation of liver resection volume in patients undergoing major hepatectomies. Accurate prediction of the planned resection and the future liver remnant (FLR) is critical to minimize the risk of postoperative liver failure, which is associated with increased morbidity and mortality. Conventional imaging-based volumetry may have limited accuracy. This study investigates the use of individualized 3D liver models combined to enhance visualization and volumetric analysis of liver anatomy and resection boundaries.

Patients are recruited in the liver outpatient clinic and, upon consent, preoperative 3D models are created using Medics 3D. During surgery, the planned resection is guided by the individualized 3D models. Postoperatively, the resected specimen undergoes CT-based volumetry to compare the predicted resection volume from the 3D model with the actual volume. Routine postoperative follow-up is conducted. The study aims to optimize surgical planning, enhance the accuracy of future liver remnant prediction.

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Key information

Conditions

Liver Surgery 3D-reconstruction Digestive System Diseases Digestive System Neoplasms Liver Liver Cancer Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Site Surgical Planning Volumetric Analysis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of Graz - Department of Surgery, Division of General, Visceral and Transplantationsurgery

Graz, Austria

Location contact

Mohamed El-Mahrouk, MD

CONTACT

[email protected]

+43 316 385 81191

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years) undergoing open or minimally invasive major liver resection at the Clinical Division of General, Visceral and Transplant Surgery who provide written informed consent prior to participation will be included.

Exclusion criteria

  • Patients unable to provide informed consent will be excluded.
  • Minor resections.
  • Contraindications to MRI.

Treatment and study plan

3D reconstruction

Diagnostic Test

Preoperatively, every patient in this study will undergo an individualized 3D reconstruction of their liver to perform accurate volumetry.

Primary outcomes

  1. Assessment of the preoperative volumetry of the liver portion planned for resection using a 3D model and comparison with the postoperative resection specimen volume.

    Time frame: Approximately 2-3 weeks are required between preoperative volumetry and postoperative volumetry comparison.

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Accuracy of Individualized 3D Reconstruction in Predicting Liver Resection Volume: A Prospective Study

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Dec 22, 2025
Registry last updated
Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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