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Completed

NCT Number: NCT02217605

31P Magnetic Resonance Spectroscopy Fructose Study

The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.

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Key information

Conditions

Healthy Digestive System Diseases Fatty Liver Liver Diseases Non-alcoholic Fatty Liver Disease

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Nottingham

Nottingham, Nottinghamshire, NG7 2RD, United Kingdom

About this study

This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Age 18 - 30
  • BMI 20 - 27 kg/m^2
  • Healthy

Exclusion criteria

  • Smokers
  • Liver disease or Metabolic Disorders
  • Metal implants (not suitable for MRI)

Treatment and study plan

Fructose

Dietary Supplement

Oral Fructose Challenge (75 g fructose in 500 ml water) following overnight fast

Primary outcomes

  1. Hepatic ATP reserves following an oral fructose challenge

    Time frame: 2 hours post prandial

    Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy

Secondary outcomes

  1. Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen

    Time frame: 2 hours post prandial

    Measure baseline liver lipid and glycogen using magnetic resonance spectroscopy and correlate BMI, lipid and glycogen levels with rate of ATP depletion and recovery following an oral fructose challenge

Sponsors and collaborators

Lead sponsor

Stephen Bawden

Other

Collaborators

  • Biotechnology and Biological Sciences Research Council
  • Unilever R&D

Registry information

Official study title

Investigating the Effects of an Oral Fructose Challenge on Hepatic ATP Reserves in Healthy Volunteers

Acronym: 31PMRS_FRU

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Aug 15, 2014
Registry last updated
Aug 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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