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Completed

NCT Number: NCT07156071

12-Week Study on the Efficacy of Two Serums in Improving Skin Aging and Tone

This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks.

A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.

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Key information

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

Shanghai, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chinese female aged 18-45 years (evenly split among Early aging [18-29 years] and Mature aging [30-45 years]).
  • All skin types (dry, normal, oily, or mixed).
  • Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed.
  • Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:
  • Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9);
  • Size of acne marks (PIH): size ≥ 2;
  • Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57).
  • Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:
  • Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9);
  • Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57);
  • Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33);
  • Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41).
  • Regular user of serum and sunscreen products.
  • Did not participate in any clinical test or cosmetic product test on skin within the last 3 months.
  • No exclusion by dermatologist due to other medical or dermatological reasons.
  • In general good health at the time of the study.
  • Willing and able to participate as evidenced by signing of informed consent and photo release form.
  • Must be willing to comply with all study protocol requirements (including using only the skincare products provided during the study and not taking topical or oral treatments such as retinol, hormones, or antioxidant health supplements).

Treatment and study plan

Serum 1

Other

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.

Serum 2

Other

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.

Primary outcomes

  1. Change in Dermatologist-Assessed Wrinkle Attributes

    Time frame: from Baseline to Week 12

    Crow's feet wrinkles, forehead wrinkles, global wrinkles, small folds on nasolabial zone and global fine lines will be evaluated by dermatologist.

  2. Self-assessment Questionnaire

    Time frame: 12 weeks

    Participants will complete a 5-point self-assessment questionnaire at Timm, T4w, T8w, and T12w, evaluating their perception of skin softness, smoothness, plumpness, elasticity, hydration, oil control, and visible aging signs. Ratings from 4 to 5 will be used to calculate "Top 2 box" percentage.

  3. Change in Dermatologist-Assessed Skin Texture and Quality Attributes

    Time frame: from Baseline to Week 12

    Skin smoothness (visual), skin elasticity, skin softness, skin firmness, skin plumpness, cheek pores will be evaluated by dermatologist.

  4. Change in Dermatologist-Assessed Skin Tone Attributes

    Time frame: from Baseline to Week 12

    Skin radiance, skin translucency, skin pigmentation, skin fairness, skin tone evenness and skin dullness will be evaluated by dermatologist.

Secondary outcomes

  1. Change in Skin Hydration Measured by Corneometer

    Time frame: 12 weeks

  2. Change in Skin Elasticity Measured by Cutometer

    Time frame: 12 weeks

  3. Change in Transepidermal Water Loss (TEWL) Measured by Vapometer

    Time frame: 12 weeks

  4. Change in Facial Image-Based Skin Parameters Using VISIA-CR

    Time frame: 12 weeks

  5. Change in Cheek Skin Surface Condition Using VisioScan VC20

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

ChinaNorm

Industry

Registry information

Official study title

12-Week Serum Efficacy Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 4, 2025
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.