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NCT Number: NCT07443566

10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology

This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.

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Key information

Conditions

Hip Fractures (ICD-10 72.01-72.2) Alzheimer s Disease Brain Diseases Central Nervous System Diseases Dementia Femoral Fractures Fractures, Bone Hip Fractures Hip Injuries Leg Injuries Mental Disorders Nervous System Diseases Neurocognitive Disorders Wounds and Injuries

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sahlgrenska University Hospit

Mölndal, Västra Götaland County, 431 80, Sweden

About this study

Participants were originally included during admission for acute hip fracture (October 2013-June 2015) at Sahlgrenska University Hospital, Mölndal, Sweden, and underwent lumbar CSF sampling at spinal anesthesia induction. Cognitive status prior to the fracture was assessed using CDR. Mortality will be ascertained through Swedish national registries. The follow-up extends survival assessment to approximately 10 years after surgery. Analyses will compare survival across baseline cognitive status categories and biomarker-defined groups (e.g., normal vs abnormal Aβ42/Aβ40 ratio), and may adjust for baseline covariates (e.g., age, sex, ASA class / hip fracture risk scores if available from original dataset).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participant enrolled in the original acute hip fracture cohort (index surgery during Oct 2013-Jun 2015 at Sahlgrenska University Hospital, Mölndal)
  • Available personal identity number enabling linkage to Swedish registries
  • Baseline cognitive assessment (CDR) and/or CSF biomarker data available from the index admission

Exclusion criteria

Missing linkage information preventing ascertainment of vital status

-

Treatment and study plan

Primary outcomes

  1. All-cause mortality / survival at 10 years after index hip fracture surgery

    Time frame: up to 10 years post-surgery

Secondary outcomes

  1. Time to death from date of surgery (survival time)

    Time frame: 10 years ( up to 10 years post-surgery)

    All-cause mortality /survival at 10 years after index hip fracture surgery

  2. Association between baseline CDR category and long-term mortality

    Time frame: up to 10 years

Sponsors and collaborators

Lead sponsor

Bengt Nellgård

Other

Registry information

Official study title

10-Year Follow-up of Mortality in Patients With Acute Hip Fractures: Associations With Pre-Alzheimer's/Alzheimer's Disease and Cerebrospinal Fluid Biomarkers

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Mar 2, 2026
Registry last updated
Mar 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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