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NCT Number: NCT02013882

1-1-12 Wash-in for Desflurane Low Flow Anesthesia

We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.

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Key information

Conditions

Anesthesia

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Srinagarind Hospital

Khon Kaen, 40002, Thailand

About this study

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA classification I-II
  • age 18-64 years

Exclusion criteria

  • BMI > 35
  • contraindicated for N2O
  • with pulmonary or cardiac disease

Treatment and study plan

1-1-12 wash-in

Procedure

wash-in phase during start of low flow anesthesia

Primary outcomes

  1. Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%

    Time frame: participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes

Secondary outcomes

  1. Heart rate

    Time frame: participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes

Sponsors and collaborators

Lead sponsor

Khon Kaen University

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Dec 17, 2013
Registry last updated
Feb 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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