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Completed

NCT Number: NCT04403971

0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia

Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among hospitalized patients.

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Key information

Conditions

Hospital-acquired Pneumonia Cross Infection Disease Attributes Healthcare-Associated Pneumonia Iatrogenic Disease Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Respiratory Tract Diseases Respiratory Tract Infections

Age range

20 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yen-Chin Chen

Tainan, 722, Taiwan

About this study

Participants will be classified into three groups, applied twice a day by care givers. Oral colonization will be tested in the baseline, day-3, day-7, and at the discharge. Quantitation of colonization of the oral cavity by oral rinses and respiratory pathogens were measured.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hospitalized patients > 20 years old without ventilator

Exclusion criteria

  • known hypersensitivity to or intolerance of Chlorhexidine or Listerine

Treatment and study plan

0.12% Chlorhexidine Oral Liquid Product

Drug

The intervention group 1 received 10ml 0.12% chlorhexidine solution for oral rinse twice a day.

Listerine Oral Liquid Product

Drug

The intervention group 2 received 10ml Listerine solution for oral rinse twice a day.

Normal Saline Product

Other

The control group received 10ml normal saline for oral rinse twice a day.

Primary outcomes

  1. oral bacterial colonization status

    Time frame: 1 year

Secondary outcomes

  1. The rate of non-ventilator associated pneumonia

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

National Cheng-Kung University Hospital

Other

Registry information

Official study title

Effect of 0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia Among Hospitalized Patients

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
May 27, 2020
Registry last updated
Dec 14, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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